Synergists for Retinoid in Cellular Differentiation of Human Promyelocytic Leukemia Cells HL-60.
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چکیده
منابع مشابه
Characterization of human alpha-dystrobrevin isoforms in HL-60 human promyelocytic leukemia cells undergoing granulocytic differentiation.
The biochemical properties and spatial localization of the protein alpha-dystrobrevin and other isoforms were investigated in cells of the human promyelocytic leukemia line HL-60 granulocytic differentiation as induced by retinoic acid (RA). Alpha-dystrobrevin was detected both in the cytosol and the nuclei of these cells, and a short isoform (gamma-dystrobrevin) was modified by tyrosine phosph...
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One of the most readily quantitated indices of myeloid maturation in HL-60 cells is their ability to respond to the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate with increased respiratory burst activity. HL-60 cells exposed to the antileukemic drug, 5-azacytidine (3 to 5 microM) for 24 hr and subsequently cultured in its absence for 2 to 3 days develop an enhanced ability to respond to ...
متن کاملDifferentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.
Differentiation refers to the ability of cancer cells to revert to their normal counterparts, and its induction represents an important noncytotoxic therapy for leukemia, and also breast, prostate, and other solid malignancies. Flavonoids are a group of differentiation-inducing chemicals with a potentially lower toxicology profile than retinoids. Flavonoid-rich polyphenol fractions from the pom...
متن کاملL-Ethionine as an inducer of differentiation in human promyelocytic leukemia cells (HL-60).
The methionine analog, L-ethionine, induces morphological and biochemical changes in cultured HL-60 cells which are indicative of myeloid maturation. After 3 to 5 days of growth in the presence of L-ethionine, the majority of cells have enhanced phagocytic ability. The percentage of cells in the culture which bear complement receptors and which can respond to 12-O-tetradecanoylphorbol-13-acetat...
متن کاملCell surface membrane protein changes during the differentiation of cultured human promyelocytic leukemia HL-60 cells.
The human promyelocytic leukemia cell line HL-60 was induced to differentiate in vitro by treatment with dimethyl sulfoxide or retinoic acid. Morphological maturation was accompanied by a total loss of transferrin binding and a 7-fold increase in the percentage of cells reducing nitro blue tetrazolium. Cell surface membrane proteins and glycoproteins were labeled with 125I by the lactoperoxidas...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1995
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.43.1827